Carboplatin CAS# 41575-94-4

Carboplatin (Brand name: Paraplatin) is a kind of chemotherapy medication used for the treatment of a series of cancers. It can be used for the treatment of various kinds of cancers including ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. Moreover, it may also be used for treating some types of testicular cancer. Carboplatin belongs to a kind of alkylating agent. It takes effect through three major mechanisms: (1) Attach the alkyl groups to the DNA bases, further causing DNA fragmentation so that DNA replication is inhibited; (2) Cause DNA damage through inducing the formation of cross-links which prevents DNA from being separated for synthesis or transcription; (3) Induce mispairing of the nucleotides leading to mutations.

Carboplatin CAS# 41575-94-4

arboplatin Basic information
Description Uses Mechanism of action
Product Name: Carboplatin
Synonyms: 1-cyclobutanedicarboxylato(2-)-o,o’)-diammine((sp-4-2)-platinu;1-cyclobutanedicarboxylato)diammine-(cis-platinum(ii;DIAMMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM(II);CARBOPLATIN;CARBOPLATINUM;CIS-DIAMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM;CIS-DIAMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM(II);CIS-DIAMMINE-[1,1-CYCLOBUTANE-DICARBOXYLATO]PLATIN
CAS: 41575-94-4
MF: C6H12N2O4Pt
MW: 371.25
EINECS: 255-446-0
Product Categories: API;Inhibitors;Anti cancer;Anti can;NEMAZINE;metal-ammine complexes;anti-cancer;Antitumors for Research and Experimental Use;Biochemistry;Classes of Metal Compounds;Cyclobutanes & Cyclobutenes;Pt (Platinum) Compounds;Simple 4-Membered Ring Compounds;Transition Metal Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients;Pharmaceutical material and intermeidates
Mol File: 41575-94-4.mol
Carboplatin Structure
Carboplatin Chemical Properties
Melting point 228-230°C
storage temp. 2-8°C
solubility Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form crystal
color white
Water Solubility Soluble in water.
Merck 14,1822
Stability: Stable. Incompatible with strong oxidizing agents.
InChI InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
InChIKey OLESAACUTLOWQZ-UHFFFAOYSA-L
SMILES C12(CCC1)C(=O)O[Pt]OC2=O.N.N
EPA Substance Registry System Carboplatin (41575-94-4)
Safety Information
Hazard Codes T
Risk Statements 46-61-20/21/22-42/43-20/21
Safety Statements 53-22-26-36/37/39-45
RIDADR 2811
WGK Germany 3
RTECS TP2300000
HS Code 28439000
Hazardous Substances Data 41575-94-4(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld)

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